From Algorithms to Clinical Decisions

MD-Paedigree final conference, hosted by the Ospedale Pediatrico Bambino Gesù (OPBG)

Rome, 22-23 May, 2017


The meeting at a glance

CDSSs – What’s new?

State-of-the-art CDSSs presented for the first time by the MD-Paedigree developers from different European research institutions

Meet experts

World-renowned clinicians all in the same place, discussing best applications and use case scenarios of CDSSs in the clinical setting

Validation challenge

How to bring innovation in clinical practice? Let’s discuss models validation and applicability in the clinical routine

OPBG Auditorium S. Paolo | Viale Ferdinando Baldelli, 38



09:00am to 09:30am

Welcome coffee

09:30am to 09:45am

Welcome address and logistic clarifications for starting the Parallel Workshops

Speaker: Bruno Dallapiccola, OPBG

10.00am to 18.30pm - Parallel Workshops on MD-Paedigree Outcomes
11.00am to 11.30am / 16.30pm to 17.00pm Coffee breaks | 13.00pm to 14.00pm Lunch Break

10:00am to 10:20am

The importance of modifying cardiologic risk factors in children and adolescent

Proposed Speaker: Andrew Taylor, University College London

10:20am to 11.00am

Patient-Specific Heart Model in Children with Dilated Cardiomyopathy

Proposed Speakers: JTitus Kühne / Marcus Kelm, DHZB - Gabriele Rinelli, OPBG

11:30am to 12:10pm

Cardiovascular disease’s risk in Obesity: a comprehensive modelling for risk assessment

Proposed Speakers: Alexander Jones, Oxford University - Melania Manco, OPBG

12:10pm to 13:30pm

Demo of Modelling Applications in Cardiomyopathies and in Obesity CVD

Proposed Speakers: Tobias Heimann, Siemens Healthcare - Klaus Dreschler, Fraunhofer IGD - Xavier Pennec, Asclepios, INRIA - Tommaso Mansi, SMS

14:30pm to 14:50pm

The potential role of analytics in cardiac diseases

Proposed Speaker: Olivier Pauly, Siemens Healthcare

14:50pm to 15:10pm

Potential workflow changes in the cardiac sector

Proposed Speakers: Karl Stroetmann / Rainer Thiel, Empirica

15:10pm to 16:00pm

Panel discussion

Proposed Speakers: Marcello Chinali, OPBG - Mario Carminat, Gruppo San Donato, Milano - Vibeke Hjortdal, Aarhus University Hospital - Willem A. Helbing, Erasmus University Medical Center - Andrew Taylor, GOSH, UCL - Jean-Benoît Thambo, Hôpital Cardiologique du Haut Lévêque

10:00am to 10:30am

Neuromuscular diseases – from gait analysis to personalized models and rehabilitation pathways

Proposed Speaker: Jaap Harlaar, VUmc

Harmonised clinical practice

Proposed Speakers: Marjolein van der Krogt, VUmc - Marije Goudriaan, KUL - Eline Flux, Vumc - Jessica Vasco, OPBG

10:30am to 13:00pm

Demo of Modelling Applications

Proposed Speakers: Frans Steenbrink, MOTEK - Thomas Geitenbeek, Delft Technical University - Maria J. Costa, Siemens Healthcare - José Pozo, University of Sheffield

14:30pm to 16:00pm

Panel discussion: Modelling solutions

Proposed Speakers: Kaat Desloovere, Katholieke Universiteit Leuven - Enrico Castelli, OPBG - Enrico Bertini, OPBG - Annemieke Buizer, VUmc - Kenneth Meijer, Maastricht University

10:00am to 10:20am

What is Juvenile Idiopathic Arthritis?

Proposed Speaker: Alberto Martini, IGG

10:20am to 10:40am

Novel therapeutic patient-specific approaches to JIA and stratifying strategies

Proposed Speaker: Fabrizio De Benedetti, OPBG

10:40am to 11:20am

From anatomy to function: what have we learnt?

Proposed Speakers: Clara Malattia, IGG - Claudia Mazzà, INSIGNEO

12:00pm to 12:20pm

Towards high-throughput data processing

Proposed Speaker: Stefan Wesarg, Fraunhofer IGD

12:20pm to 12:40pm

Luminex outcomes

Proposed Speaker: Berent Prakken, UMCU

14:30pm to 16:00pm

Panel discussion

Proposed Speakers: Gian Michele Magnano / Francesca Magnaguagno, IGG - Paolo Tomà / Laura Tanturri, OPBG - Paolo Moretti, IGG - Maurizio Petrarca, OPBG - Jelena Vojinovic, NIS (still to be confirmed) - Esperanza Naredo, Hospital Universitario g. Maranon, Madrid (still to be confirmed)

10:00am to 10:30am

Microbiome clinics

Proposed Speakers: Joel Doré, INRA – Metagenopolis - Lorenza Putignani, OPBG

Microbiome based diagnostics

10:30am to 13:00pm

Clinical applications in JIA
JIA predictive microbioma modelling

Proposed Speakers: Pieter van Dijkhuizen, UMCU - Federico Marini, URLS - Federica del Chierico, OPBG - Jakob Hauser, UCL

14:00pm to 16:00pm

Genomics in cardiovascular diseases

Proposed Speakers: Barbara Simionati, BMR Genomics - Willem M. de Vos, Wageningen University - Antonio Gasbarrini, UCSC

10:00am to 10:20am

The MD-Paedigree Infostructure

Proposed Speaker: David Manset, gNὑbila

10:20am to 11:00am

Data Analytics solutions

Proposed Speakers: Emilie Pasche, HES-SO Omiros Metaxas, ATHENA RC - Dominik Neumann, Siemens Healthcare

11:30am to 12:00pm

Anonymization and curation tools in a big data environment and permissions systems

Proposed Speakers: Rose Esmander, gNubila Harry Dimitropoulos, ATHENA RC

14:30pm to 16:00pm

Panel discussion on semantic interoperability, data management, availability, access, and user-friendliness

Proposed Speakers: Mona Alimohammadi, UCL Henning Mueller, HES-SO Steven Wood, University of Sheffield Isabelle Hilali, Centre de Recherche Interdisciplinaire, Paris Ferath Kherif, Human Brain Project, PFUL Marco Manca, CERN

11:30am to 11:50am

Brief description of MD-Paedigree’s goals and achievements

Proposed Speaker: Edwin Morley-Fletcher, Lynkeus, Rome

11:50am to 12:10pm

Ethical evaluation criteria applied to MD-Paedigree

Proposed Speaker: Laura Palazzani, Libera Università Maria Santissima Assunta - LUMSA, Rome

12:10pm to 12:30pm

Consent of parents on behalf of children and when do minors come of age for this purposes

Proposed Speaker: Linda Nielsen, University of Copenhagen

12:30pm to 12:50pm

Patients’ rights and research usages of their data

Proposed Speaker: Herman Nys, KU LEUVEN

12:50pm to 13:10pm

Social impact and awareness of ethical implications in personalized medicine

Proposed Speaker: Laurence Claeys, Vreje Universiteit Brussels

12:30pm to 16:00pm

Panel with representatives of European and national Patient Associations

Chair: Mariella Enoc, President, OPBG

16:30pm to 16:40pm

Welcome Address

Speaker: Bruno Dallapiccola, Scientific Director, OPBG

16:40pm to 16:50pm

Big Data from Horizon 2020 to FP9

Speaker: Marco Falzetti, Agenzia per la Promozione della Ricerca (APRE), Rome

16:50pm to 17:10pm

Public Health Genomics towards Personalised Medicine

Speaker: Walter Ricciardi, Istituto Superiore di Sanità, Rome

16:10pm to 17:30pm

Personalised Medicine’s Impact at the European level

Speaker: Mrs Carmen Laplaza Santos, DG Connect, European Commission

17:30pm to 18:10pm

Big Data and Data Analytics in Healthcare

General outlook: Torsten Niederdrank, Siemens

MD-Paedigree’s approach: Patrick Ruch, HES-SO

19:00pm to 21:00pm - Private evening visit to the Vatican Museums

Chairman: B. Dallapiccola

09:00am to 09:30am

The clinical potential of meta Omics

Proposed Speaker: Ted Dinan, APC Microbiome Institute

MD-Paedigree’s approach: Bruno Dallapiccola, Scientific Director, OPBG

09:30am to 10:00am

What can be the role of CDSS in Paediatric Clinical Practice

Proposed Speaker: Anthony C. Chang, iSPI

MD-Paedigree’s approach: Edwin Morley-Fletcher, Lynkeus

10:00am to 11:00am

How to Win the Validation Challenge

MD-Paedigree’s general validation approach: Marcello Chinali, OPBG

Methodological and sectorial outlook: Marco Viceconti, INSIGNEO, Liesbeth Geris, Director, VPH Institute, Marta Bertolaso, Biomedic Campus, Thomas Geijtenbeek, TU Delft

11:00am to 11:30am - Coffee break

11:30am to 12:00pm

How to guarantee the ongoing availability of research data. From local availability to distributed access

Proposed Speaker: John Ioannidis, Stanford University

MD-Paedigree’s approach: David Manset, Gnứbila

12:00pm to 12:30pm

The ethical and legal framework for within which can operate a model-driven health data repository

General outlook: yet to be identified

MD-Paedigree’s approach: Laura Palazzani, Libera Università Maria Santissima Assunta - LUMSA, Rome

12:30pm to 13:00pm

The value of a common, transnational and digitally trustable Infostructure

Proposed Speaker: Benoit Schoeffler, Almerys

MD-Paedigree’s approach: Yannis Ioannidis, Athena RC

13:40pm to 14:30pm - Lunch break

Chairman: B. Dallapiccola

14:30pm to 16:00pm

Plenary Summary of MD-Paedigree Outcomes and Internal Reviewers’ Assessments

Proposed Speakers: Alex Jones / Gabriele Rinelli / Tammo Delhaas / Alberto Martini / Rolando Cimaz / Jaap Harlaar / Adam Shorthand / Lorenza Putignani / Maria Krestyaninova / David Manset / Alberto Sanna / Marcello Chinali / Marta Bertolaso

16:00am to 16:30am - Coffee break

16:30am to 17:30pm

Governing Board and Wrap-up