From Algorithms to Clinical Decisions

MD-Paedigree final conference, hosted by the Ospedale Pediatrico Bambino Gesù (OPBG)

Rome, 22-23 May, 2017

The meeting at a glance

CDSSs – What’s new?

State-of-the-art CDSSs presented for the first time by the MD-Paedigree developers from different European research institutions

Meet experts

World-renowned clinicians all in the same place, discussing best applications and use case scenarios of CDSSs in the clinical setting

Validation challenge

How to bring innovation in clinical practice? Let’s discuss models validation and applicability in the clinical routine

OPBG Auditorium S. Paolo | Viale Ferdinando Baldelli, 38



09:00am to 09:30am

Welcome coffee

09:30am to 09:45am

Welcome address and logistic clarifications for starting the Parallel Workshops

Speaker: Bruno Dallapiccola, OPBG

10.00am to 16.00pm - Parallel Workshops on MD-Paedigree Outcomes
11.00am to 11.30am / 16.00pm to 16.30pm Coffee breaks | 13.30pm to 14.30pm Lunch Break

10:00am to 10:20am

The importance of modifying cardiologic risk factors in children and adolescent

Speaker: Andrew Taylor, University College London

10:20am to 11.00am

Patient-Specific Heart Model in Children with Dilated Cardiomyopathy

Speakers: Franziska Degener, DHZB - Marcello Chinali, OPBG

11:30am to 12:10pm

Cardiovascular disease’s risk in Obesity: a comprehensive modelling for risk assessment

Speakers: Alexander Jones, Oxford University - Melania Manco, OPBG

12:10pm to 12:30pm

The potential role of analytics in cardiac diseases

Speaker: Olivier Pauly, Siemens Healthcare

12:30pm to 13:30pm

Demo of Modelling Applications in Cardiomyopathies and in Obesity CVD

Speakers: Tobias Heimann, Siemens Healthcare - Klaus Dreschler, Fraunhofer IGD - Xavier Pennec, Asclepios, INRIA - Dominik Neumann, Siemens Heathcare - Viorel Mihalef, Siemens

14:30pm to 14:50pm

Potential workflow changes in the cardiac sector

Speaker: Karl Stroetmann, Empirica

14:50pm to 16:00pm

Panel discussion

Speakers: Gabriele Rinelli, OPBG - Anja Hennemuth, Fraunhofer - Jean-Benoît Thambo, Hôpital Cardiologique du Haut Lévêque - Aurelio Secinaro, OPBG - Vibeke E. Hjortdal, Aarhus Hospital

10:00am to 10:20am

Neuromuscular diseases – from gait analysis to personalized models and rehabilitation pathways

Speaker: Jaap Harlaar, VUmc

10:20am to 11:00am

Harmonised clinical practice

Speakers: Marjolein van der Krogt, Vumc - Eline Flux, Vumc - Marije Goudriaan, KUL -

11:30am to 13:30pm

Demo of Modelling Applications

Speakers: Frans Steenbrink, MOTEK - Thomas Geitenbeek, Delft Technical University - Maria J. Costa, Siemens Healthcare - José Pozo, University of Sheffield

14:30pm to 16:00pm

Panel discussion: Modelling solutions

Speakers: Kaat Desloovere, Katholieke Universiteit Leuven - Enrico Castelli, OPBG - Enrico Bertini, OPBG - Annemieke Buizer, VUmc - Kenneth Meijer, Maastricht University, OPBG - Maurizio Petrarca, OPBG

10:00am to 10:20am

What is Juvenile Idiopathic Arthritis?

Speaker: Alberto Martini, IGG

10:20am to 11:00am

From anatomy to function: what have we learnt?

Speakers: Clara Malattia, IGG - Claudia Mazzà, USFD

11:00am to 11:30am

Coffee break

11:30am to 11:55am

Novel therapeutic patient-specific approaches to JIA and stratifying strategies

Speaker: Fabrizio De Benedetti, OPBG

11:55am to 12:25pm

Towards high-throughput data processing

Speaker: Stefan Wesarg, Fraunhofer

12:25pm to 12:50pm

Luminex outcomes

Speaker: Sebastian Vastert, UMCU

12:50pm to 13:30pm

Challenges in the prediction of the prognosis of JIA patients

Speaker: Pieter van Dijkhuizen, UMCU - Orfeas Adinopoulous

13:30pm to 14:30pm

Lunch break

14:30pm to 16:00pm

Panel discussion

Speakers: Jelena Vojinovic, University of Nis, Serbia - Francesca Magnaguagno, IGG - Paolo Tomà / Laura Tanturri, OPBG - Anna Ronchetti, IGG - Eduardo Palermo, La Sapienza - Silvia Magni Manzoni, OPBG

10:00am to 10:20am

Microbiome clinics

Speakers: Antonio Gasbarrini, UCSC

10:20am to 10:40am

Microbiome based diagnostics

Speakers: Lorenza Putignani, OPBG

10:40pm to 11:00pm

Genomics in cardiovascular diseases

Speaker: Anwar Baban, OPBG -

11:00am to 11:30am

Coffee break

11:30pm to 11:50pm

Clinical applications in Obesity

Speaker: Jakob Hauser, UCL

11:50am to 12:15pm

Clinical applications in JIA

Speaker: Pieter van Dijkhuizen, UMCU

12:15am to 13:30pm

JIA predictive microbioma modelling

Speakers: Federico Marini, Department of Chemistry - Sapienza University of Rome - Federica del Chierico, OPBG - Pamela Vernocchi, OPBG

13:30pm to 14:30pm

Lunch break

14:30pm to 16:00pm

Panel Discussion

Speakers: Alfredo Miccheli, Department of Chemistry - Sapienza University of Rome - Melania Manco, OPBG

16:00pm to 16:30pm

Coffee break

10:00am to 10:20am

The MD-Paedigree Infostructure

Speaker: David Manset, gNὑbila - Orfeas Adinopoulous, ATHENA RC

10:20am to 11:00am

Data Analytics solutions

Speakers: Emilie Pasche, HES-SO - Harry Dimitripoulos, ATHENA RC

11:30am to 12:10pm

Anonymization and curation tools in a big data environment and permissions systems

Speakers: Rose Esmander, gNubila - Harry Dimitropoulos, ATHENA RC

12:10am to 13:30pm

Demo session

Speakers: Jerome Revilllard, gNubila

14:30pm to 16:00pm

Panel discussion on semantic interoperability, data management, availability, access, and user-friendliness

Speakers: Henning Mueller, HES-SO - Rod Hose, University of Sheffield tbc - Isabelle Hilali, Centre de Recherche Interdisciplinaire, Paris - Ferath Kherif, Human Brain Project, PFUL - Marco Manca, CERN

11:30am to 12:00pm

Brief description of MD-Paedigree’s goals and achievements

Speaker: Edwin Morley-Fletcher, Lynkeus, Rome

12:00am to 12:20pm

Ethical evaluation criteria applied to MD-Paedigree

Speaker: Laura Palazzani, Libera Università Maria Santissima Assunta - LUMSA, Rome

12:20pm to 12:40pm

Consent of parents on behalf of children and when do minors come of age for this purposes

Speaker: Linda Nielsen, University of Copenhagen

12:40pm to 13:10pm

Social impact and awareness of ethical implications in personalized medicine

Speaker: Laurence Claeys, Vreje Universiteit Brussels

13:10pm to 13:30pm

Privacy in the era of big data

Speaker: Siobhan O’Sullivan, EGE

13:30pm to 14:30pm

Lunch break

14:30pm to 16:00pm

Panel discussion

Speaker: Laura Palazzani, Libera Università Maria Santissima Assunta, LUMSA, Rome - Linda Nielsen, University of Copenhagen - Laurence Claeys, Vreje Universiteit Brussels - Siobhan O’Sullivan, EGE - Alberto Eugenio Tozzi, Bambino Gesù Paediatric Hospital - Edwin Morley Fletcher, Lynkeus

16:00pm to 16:30pm

Coffee break

Chair: Bruno Dallapiccola, President, OPBG

16:30pm to 16:40pm

Welcome Address

Speaker: Bruno Dallapiccola, Scientific Director, OPBG

16:40pm to 16:55pm

Big Data from Horizon 2020 to FP9

Speaker: Marco Falzetti, Agenzia per la Promozione della Ricerca (APRE), Rome

16:55pm to 17:10pm

Public Health Genomics towards Personalised Medicine

Speaker: Walter Ricciardi, Istituto Superiore di Sanità, Rome

17:10pm to 17:25pm

Personalised Medicine’s Impact at the European level

Speaker: Terje Peetso, Head of Policy Sector - Unit eHealth, Wellbeing & Ageing/H3 - DG Connect, European Commission

17:25pm to 18:05pm

Big Data and Data Analytics in Healthcare

General outlook: Torsten Niederdrank, Siemens

MD-Paedigree’s approach: Patrick Ruch, HES-SO

19:00pm to 23:00pm - Private evening visit to the Vatican Museums

Chairman: B. Dallapiccola

09:00am to 09:30am

The clinical potential of meta Omics

General outlook: Dr Yolanda Sanz, CSIC Spanish National Research Council

MD-Paedigree’s approach: Lorenza Putignani, OPBG - Bruno Dallapiccola, Scientific Director, OPBG

09:30am to 09:45am

What can be the role of CDSS in Paediatric Clinical Practice

MD-Paedigree’s approach: Edwin Morley-Fletcher, Lynkeus - Davide Zaccagnini, Lynkeus

09:45am to 11:00am

How to Win the Validation Challenge

MD-Paedigree’s general validation approach: Marcello Chinali, OPBG

Methodological and sectorial outlook: Marco Viceconti, Sheffield University - Liesbeth Geris, Director, VPH Institute - Thomas Geijtenbeek, TU Delft - Marta Bertolaso, Biomedic Campus

11:00am to 11:30am - Coffee break

11:30am to 12:00pm

How to guarantee the ongoing availability of research data. From local availability to distributed access

General outlook: Natalia Manola, University of Athens – Open Aire Project

MD-Paedigree’s approach: David Manset, Gnứbila

12:00pm to 12:30pm

The ethical and legal framework for within which can operate a model-driven health data repository

MD-Paedigree’s approach: Laura Palazzani, Libera Università Maria Santissima Assunta - LUMSA, Rome

12:30pm to 13:10pm

The value of a common, transnational and digitally trustable Infostructure

Speaker: Benoit Schoeffler, Almerys

MD-Paedigree’s approach: Yannis Ioannidis, Athena RC

13:10pm to 14:30pm - Lunch break

Chairman: Edwin Morley Fletcher

14:30pm to 16:00pm

Plenary Summary of MD-Paedigree Outcomes and Internal Reviewers’ Assessments

Speakers: Alex Jones / Gabriele Rinelli / Tammo Delhaas / Fabrizio De Benedetti / Rolando Cimaz / Jaap Harlaar / Adam Shorthand / Lorenza Putignani / Maria Krestyaninova / David Manset / Alberto Sanna / Marcello Chinali / Marta Bertolaso

16:00am to 16:30am - Coffee break

16:30am to 17:30pm

Governing Board and Wrap-up