In paediatric cardiovascular disease, predicting how patients will respond to treatments, which treatments to use, and when to treat can be difficult to define due to small patient numbers and limited outcome data. MD-Paedigree will re-use the models developed in Health-e-Child and Sim-e-Child and extend them to cardiomyopathies. Read the Clinical Application Scenario Clinical Concept: [...]

Obesity as one of the primary risk factors for cardiovascular disease (CVD), a risk factor that originates early in life. MD‐Paedigree will develop computational models with high predictive power to better understand the mechanism of CVD development.  Read the Clinical Application Scenario Clinical Concept: The World Health Report 2002 revealed that, in developed countries, approximately [...]

Juvenile idiopathic arthritis (JIA) is a broad term that describes a clinically heterogeneous group of arthritis which has an onset before age of 16 years. JIA which affects approximately one in 1,000 children represents the leading cause of childhood disability from a musculoskeletal disorder.   Read the Clinical Application Scenario Clinical Concept: Juvenile idiopathic arthritis (JIA) [...]

The most common paediatric disorder within the NND disease area is Cerebral Palsy (CP) whose incidence ranges between 2 to 3.6 per 1,000 live births. The second important disorder is Spinal Muscular Atrophy (SMA). [...]   Read the Clinical Application Scenario Clinical Concept: In Neurological and Neuromuscular Diseases (NND) as well as in certain chronic paediatric [...]